Eu encontrei uma edição de registro fácil neste site. link
Editar: Aqui está o que o REG desta página contém:
Windows Registry Editor Version 5.00
;Disables F1 key - Help and Support - in Windows 10
;Ramesh Srinivasan, Winhelponline.com
[HKEY_CURRENT_USER\SOFTWARE\Classes\Typelib\{8cec5860-07a1-11d9-b15e-000d56bfe6ee}.0Windows Registry Editor Version 5.00
;Disables F1 key - Help and Support - in Windows 10
;Ramesh Srinivasan, Winhelponline.com
[HKEY_CURRENT_USER\SOFTWARE\Classes\Typelib\{8cec5860-07a1-11d9-b15e-000d56bfe6ee}.0%pre%\win32]
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[HKEY_CURRENT_USER\SOFTWARE\Classes\Typelib\{8cec5860-07a1-11d9-b15e-000d56bfe6ee}.0%pre%\win64]
@=""
\win32]
@=""
[HKEY_CURRENT_USER\SOFTWARE\Classes\Typelib\{8cec5860-07a1-11d9-b15e-000d56bfe6ee}.0%pre%\win64]
@=""