A partir do último GNU Screen Changelog tem um entrada para o uso do mouse:
* 'defmousetrack' and 'mousetrack', to turn on/off mouse-tracking for
displays. It's turned off by default. With mouse-tracking turned on, it's
possible to switch to a region ('focus') using mouse clicks. It's also
possible to select a text region in copy-mode using a mouse click to place
a mark and the scroll wheel to scroll through the buffer. Additional
features might be to allow clicking on window-titles in the caption to
switch to that window.
O Debian instável parece ter a última tela do gnu com a configuração acima.
$dpkg -l screen
[...]
ii screen 4.1.0~20120320gi amd64 terminal multiplexer with VT100/ANSI terminal emu
Divirta-se!