Existe uma maneira de desabilitar este atalho ( Ctrl + Mousewheel )?
Você pode instalar o zoom-disabler plugin:
You can Zoom-in or Zoom-out in Notepad++ using,
Ctrl+Mousewheel Scroll-in or Scroll-out.
Keyboard Ctrl +NumpadPlus to Zoom-in or Ctrl+Numpad Minus to Zoom-out.
But many a times we Zoom happens by accident. Ctrl+Mouse get pressed so Zoom takes place instead of Scroll. In order to disable this functionality you need to download a plugin called "Zoom Disabler"
Installing Zoom Disabler
Goto Menu -> Plugins -> Plugin Manager
Look for Zoom Disabler and Select the Check-box and Install
After Installing the Plugin Notepad++ will restart and "Zoom Disabler" will be available under Plugins Menu.
Try Ctrl+MouseWheel in or out. Text will remain unaffected.
When you install this plugin, by default it Disables Mouse Zoom. If you want to enable it again you can do it by going to Menu -> Plugins -> Plugin Manager -> Zoom Disabler and de-select Disables Mouse Zoom
Fonte Desativar o controle Rolar Zoom-in e Zoom- no Notepad ++ - Code2Care