Para acompanhar o meu comentário à resposta do @penlite.
Do Media Monkey Wiki :
It is possible to sync certain iPods without iTunes installed. The iPod touch, iPhone, iPod classic, and iPod nano 3rd/4th generation all require certain iTunes components to be installed to sync to them. These files are usually located at C:\Program Files\Common Files\Apple\Mobile Device Support and you could uninstall iTunes as long as you kept the files at the location above. However, there are disadvantages to not keeping iTunes – for example, you can't update the device firmware or restore it without iTunes. You will also not be able to sync pictures or video without iTunes since MediaMonkey currently does not handle these file types.
Então, qualquer que seja o programa em que você se estabeleça, você ainda terá que ter o iTunes instalado.