Veja alguns scripts do AutoHotkey .
1. Mapeie o shift + wheel para eventos de roda simples no Internet Explorer
#IfWinActive ahk_class IEFrame $+WheelUp:: Send {WheelUp} $+WheelDown:: Send {WheelDown}
2. Desabilite os eventos shift + wheel no Internet Exlorer
#IfWinActive ahk_class IEFrame +WheelUp:: return +WheelDown:: return