Consegui encontrar isso com uma rápida pesquisa no google ( link ):
2.4.11.2 Debugger start fails if the IntelliTrace recordings directory is Read-Only
By default, IntelliTrace files are located in the "%ProgramData%\Microsoft Visual
Studio.0\TraceDebugging\" directory. If this directory is made read-only, or the
directory is changed to a read-only location, an uncaught exception gets raised to the
user. "Error while trying to run project: Uncaught exception thrown by method called
through Reflection."
Para resolver este problema:
* Option 1: Modify the permissions of the directory to be writable.
* Option 2: Change the directory where IntelliTrace recordings are stored.
o In Visual Studio, open the Options dialog box.
o Expand the IntelliTrace item in the left pane of the dialog box.
o Click the Advanced item under IntelliTrace.
o Change the IntelliTrace recordings directory to one that is not read-only.
o Click OK.