Primeiro, faça um backup do banco de dados existente usando o mysqldump e pare o servidor mysql. então siga estes
sudo rm /usr/local/mysql
sudo rm -rf /usr/local/mysql*
sudo rm -rf /Library/StartupItems/MySQLCOM
sudo rm -rf /Library/PreferencePanes/My*
edit /etc/hostconfig and remove the line MYSQLCOM=-YES-
rm -rf ~/Library/PreferencePanes/My*
sudo rm -rf /Library/Receipts/mysql*
sudo rm -rf /Library/Receipts/MySQL*
sudo rm -rf /private/var/db/receipts/*mysql*
sudo rm -rf /var/db/receipts/com.mysql.*