A maneira mais rápida é usar map_channel
e pan
para o downmix:
ffmpeg -i in.mov -filter_complex
"[0]pan=stereo|FL=FC+0.30*FL+0.30*BL|FR=FC+0.30*FR+0.30*BR[st]"
-map 0:v -c:v copy
-map 0:a -map_channel 0.1.0:0.1
-map 0:a -map_channel 0.1.1:0.2
-map 0:a -map_channel 0.1.2:0.3
-map 0:a -map_channel 0.1.3:0.4
-map 0:a -map_channel 0.1.4:0.5
-map 0:a -map_channel 0.1.5:0.6
-map "[st]" output.mov