Com certeza:)
# ip address list dev eth0
2: eth0: <BROADCAST,MULTICAST,UP,LOWER_UP> mtu 1500 qdisc pfifo_fast state UP qlen 1000
link/ether 00:1e:4f:9b:4a:ab brd ff:ff:ff:ff:ff:ff
inet 10.10.141.83/24 brd 10.10.141.255 scope global eth0
inet6 fe80::21e:4fff:fe9b:4aab/64 scope link
valid_lft forever preferred_lft forever
# ip address add 10.10.141.253/24 dev eth0
# ip address list dev eth0
2: eth0: <BROADCAST,MULTICAST,UP,LOWER_UP> mtu 1500 qdisc pfifo_fast state UP qlen 1000
link/ether 00:1e:4f:9b:4a:ab brd ff:ff:ff:ff:ff:ff
inet 10.10.141.83/24 brd 10.10.141.255 scope global eth0
inet 10.10.141.253/24 scope global eth0
inet6 fe80::21e:4fff:fe9b:4aab/64 scope link
valid_lft forever preferred_lft forever
# ping -I 10.10.141.83 10.10.141.253
PING 10.10.141.253 (10.10.141.253) from 10.10.141.83 : 56(84) bytes of data.
64 bytes from 10.10.141.253: icmp_seq=1 ttl=64 time=0.050 ms
64 bytes from 10.10.141.253: icmp_seq=2 ttl=64 time=0.034 ms
64 bytes from 10.10.141.253: icmp_seq=3 ttl=64 time=0.038 ms
^C
--- 10.10.141.253 ping statistics ---
3 packets transmitted, 3 received, 0% packet loss, time 1999ms
rtt min/avg/max/mdev = 0.034/0.040/0.050/0.010 ms
# ip address delete 10.10.141.253/24 dev eth0
# ping -I 10.10.141.83 10.10.141.253
PING 10.10.141.253 (10.10.141.253) from 10.10.141.83 : 56(84) bytes of data.
From 10.10.141.83 icmp_seq=1 Destination Host Unreachable
From 10.10.141.83 icmp_seq=2 Destination Host Unreachable
From 10.10.141.83 icmp_seq=3 Destination Host Unreachable
^C
--- 10.10.141.253 ping statistics ---
4 packets transmitted, 0 received, +3 errors, 100% packet loss, time 3016ms
Realmente simples e morto. :) (Brincadeira, é sempre simples se você já sabe)
Eu não tenho certeza se L2 realmente funcionaria, mas com ip neigh
você pode ser capaz de modificar o cache de arp também (tanto para simples morto)