You can use nginx with our rules by putting a reverse proxy apache with mod_security in front of nginx. Thats actually very lightweight and something we will be adding post 3.0 as an option for sites running alternative web servers like nginx, etc. As Scott said, nginx does not have any WAF module or capability, so theres no way you can do anything like modsecurity inside nginx.
People have requested the nginx team add a WAF, and I know lightspeed is working on full modsec support, but so far I havent seen anything for nginx. So if you use nginx, and you want a WAF to protect it, you will need to put a WAF in front of it.
And as I said, this works great so I highly recommend you do that. We've got a bunch of customers running all sorts of non-apache webservers with apache reverse proxies and mod_security in front of them. And as I mentioned, we will be adding this into ASL post 3.0 release as an option for non-Apache web servers.
(Gotroot.com é bem conhecido por sua lista de regras mod_security que eles fornecem.)
Outra coisa que você pode experimentar é o naxsi que é um módulo do Firewall de Aplicação Web para o Nginx, embora ainda esteja em alpha versão. Mais