Você vai querer usar o reg-load para editar o padrão ntuser.dat, que será então propagado para todos os perfis recém-criados.
Exemplo:
@echo off
SET Counter=0
SET LogFile=%windir%\temp\Reg.log
echo. > %LogFile%
:LoadRegHive
SET /A Counter += 1
sleep 5
REG LOAD HKU\ChangeMe "c:\Documents and Settings\Default User\NTUSER.DAT"
IF /I %Counter% GEQ 10 GOTO RegLoadError
IF ERRORLEVEL 0 IF NOT ERRORLEVEL 1 (SET Counter=0 && GOTO ChangeKeys) ELSE (GOTO LoadRegHive)
:ChangeKeys
REG ADD "HKEY_USERS\ChangeMe\Software\Microsoft\Windows\CurrentVersion\Explorer\User Shell Folders" /v "My Pictures" /t REG_EXPAND_SZ /d "%%SystemDrive%%\My Documents\My Pictures" /f
IF ERRORLEVEL 0 IF NOT ERRORLEVEL 1 (echo "Successfully changed My Pictures network reference" >> %LogFile%) ELSE (echo "Error changing My Pictures network reference" >> %LogFile%)
REG ADD "HKEY_USERS\ChangeMe\Software\Microsoft\Windows\CurrentVersion\Explorer\User Shell Folders" /v "My Music" /t REG_EXPAND_SZ /d "%%SystemDrive%%\My Documents\My Music" /f
IF ERRORLEVEL 0 IF NOT ERRORLEVEL 1 (echo "Successfully changed My Music network reference" >> %LogFile%) ELSE (echo "Error changing My Music network reference" >> %LogFile%)
REG ADD "HKEY_USERS\ChangeMe\Software\Microsoft\Windows\CurrentVersion\Explorer\User Shell Folders" /v "Personal" /t REG_EXPAND_SZ /d "%%SystemDrive%%\My Documents" /f
IF ERRORLEVEL 0 IF NOT ERRORLEVEL 1 (echo "Successfully changed Personal network reference" >> %LogFile%) ELSE (echo "Error changing My Music network reference" >> %LogFile%)
REG UNLOAD HKU\ChangeMe
GOTO End
:RegLoadError
echo "Error loading the registry hive after 10 tries." >> %LogFile%
GOTO END
:End
EXIT