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All of the .NET Framework versions listed in the following table are in-place updates to the .NET Framework 4. In other words, if you install a later version, such as the .NET Framework 4.6, you do not first have to install the previous versions, such as the .NET Framework 4.5, 4.5.1, or 4.5.2.
Todas as versões pós-4.0 são cumulativas; você só precisa instalar o mais recente.