Você precisa adicionar suporte multiarque. Está tentando baixar wine-i386
dpkg --add-architecture i386 && apt-get update
apt-get install wine
The following packages have unmet dependencies:
wine1.8 : Depends: wine1.8-amd64 (= 1:1.8.0-0ubuntu1~ubuntu15.10.1~ppa1) but it is not going to be installed
Depends: wine1.8-i386 (= 1:1.8.0-0ubuntu1~ubuntu15.10.1~ppa1) but it is not installable
Recommends: gnome-exe-thumbnailer but it is not installable or
kde-runtime but it is not installable
Recommends: fonts-droid but it is not installable
Recommends: ttf-mscorefonts-installer but it is not installable
Recommends: fonts-horai-umefont but it is not installable
Recommends: fonts-unfonts-core but it is not going to be installed
Recommends: ttf-wqy-microhei but it is not installable
Recommends: winetricks but it is not installable
E: Unable to correct problems, you have held broken packages.
Você precisa adicionar suporte multiarque. Está tentando baixar wine-i386
dpkg --add-architecture i386 && apt-get update
apt-get install wine