Em um email de Peter Hutterer, que mantém grande parte da pilha de entradas do Xorg:
right now, you can't unload a module without restarting the server. patches to support that were floating around at some point but never got merged.
Posso recarregar o driver xserver-xorg-input-mouse on the fly? Por exemplo, depois de modificar e recompilar a fonte
Tags xorg drivers dynamic-loading