Faça isso:
xb@dnxb:~/tmp$ shopt interactive_comments
interactive_comments on
xb@dnxb:~/tmp$ shopt -u interactive_comments
xb@dnxb:~/tmp$ shopt interactive_comments
interactive_comments off
xb@dnxb:~/tmp$ alias #='ls -la'
xb@dnxb:~/tmp$ # /tmp -d
drwxrwxrwt 14 root root 32768 Nov 2 03:09 /tmp
xb@dnxb:~/tmp$
Em ~ / .bash_aliases, escape:
shopt -u interactive_comments
alias \#='ls -la'