Isso tem uma solução simples. Há um erro no arquivo de configuração, basta remover a linha shift + ctrl + r, r:
[
// Modified Sublime-REPL keybindings for an "R-friendly" set of shortcuts.
// For more information, see http://tomschenkjr.net/2012/05/17/using-sublime-text-2-for-r/
// Executes a selection of text in REPL, latter only displays code and does not execute
{ "keys": ["ctrl+shift+r"], "command": "repl_transfer_current", "args": {"scope": "selection"}},
// Executes the entire file (build) in REPL, latter only displays code and does not execute
{ "keys": ["ctrl + f7"], "command": "repl_transfer_current", "args": {"scope": "file"}},
// Executes line(s) of text in REPL terminal, latter only displays code and does not execute
{ "keys": ["ctrl+alt+r"], "command": "repl_transfer_current", "args": {"scope": "lines"}},
// Executes a block (e.g., a custom function) of text in REPL terminal, latter only displays code and does not execute
{ "keys": ["ctrl+shift+alt+r"], "command": "repl_transfer_current", "args": {"scope": "block"}},
]