Não, o Internet Explorer 10 não suporta WebGL.
De Wikipedia :
Microsoft has not announced any plans to officially support WebGL.
In June 2011, Microsoft announced that they could not endorse WebGL in its current form from a security perspective. Analysis performed by its MSRC Engineering team concluded that WebGL support in Microsoft products would have difficulty in meeting the requirements of the Security Development Lifecycle, the software security standards internally enforced in Microsoft. Specifically, Microsoft cited overly permissive exposure of hardware functionality, heavy reliance on third parties to secure web experience, and unproven denial-of-service protection capabilities as their key concerns.
O IEWebGL pode ser instalado como um plugin.