Para a segunda parte da sua resposta, você deve dar uma olhada em esta pergunta do SuperUser
A primeira parte da sua pergunta é muito factível, se você me informar a versão do Windows que você está usando, eu postarei as etapas.
Veja também este artigo: link Principais pontos detalhados abaixo:
The driver for the device has a flag telling Windows that it is a 'removable' device, which gets loaded into the registry whenever the device is loaded. So, you basically just need to setup a way to automatically overwrite the registry value when the system boots.
First you'll need to get the ID of the device you want to remove. •Open Device Manager (Start > Run > devmgmt.msc) •Right-click on the device and go to Properties, then open the Details tab •The 'Device Instance Id' item will be selected by default in the drop-down list •It will look something like 'IDE\CDROMPBDS_DVD+RW_DS8W1P[...]\DB1B[...]&C10F4F&0&0.0.0 •Keep that window open, or write down the ID because you'll need it in the next step
The next step is to modify the removable value in the registry. •Open the registry editor (Start > Run > regedit) •Drill down to HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Enum •Then use the sections of the ID to locate the device (e.g., IDE, then CDROMPBDS_DVD+RW_DS8W1P[...]\DB1B[...] then 5&C10F4F&0&0.0.0 •By default you probably won't have permssion to modify the value, so right click on the key (folder) and go to Permissions and give your account 'Full Control' •Inside that key will be a value named 'Capabilities', which will have a value of 4 or 6 or some higher number •Right click on the value and select 'Modify,' then subtract 4 from the value (e.g., change 6 to 2, 4 to 0, etc) and click 'Ok' At this point the device isn't recognized as removable. It might take windows a moment to update the Safely Remove Hardware app, or you might have to open it up to refresh it, but the device is updated. The icon may stick around, but after the next step that will be taken care of.
The last step is to make sure that the value is automatically updated every time Windows boots (because the value is loaded from the device driver every time, so we have to overwrite it every time). •Go to File > Export and save the key to somewhere on your computer • Open it with a text editor and get rid of all the extra subkeys and values that we don't want to change. In the end it should look something like this:
Windows Registry Editor Version 5.00
[HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Enum\IDE\CdRomPBDS_DVD+-RW_DS-8W1P____________________BD1B____&c10f4f&0&0.0.0] "Capabilities"=dword:00000002
•Back in the registry editor, browse to HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Run •Right click > New > String value •Give it a name then Right click and Modify •Enter regedit /s "C:\Documents and Settings\user\My Documents\DVD Not Removable.reg" (Update the path for where you saved the file and what you named it)
Now that .reg file containing the updated value will be loaded every time you log on to your account and (assuming it was the only removable device) the Safely Remove Hardware icon won't show up anymore.
Update: Check comment #28 if you're running Windows 7 * Comment 28 loops back to the SuperUser question I linked you through to.
Para ocultar esse ícone no Windows XP, basta usar o recurso "Ocultar ícones inativos", definindo-o como "Sempre ocultar"
Clique com o botão direito do mouse em Barra de tarefas > Propriedades > Marque a opção "Ocultar ícones inativos" > Personalizar
Isso exigiria configurar seus outros ícones para uma configuração apropriada, por exemplo, "Mostrar sempre"