A diferença no tamanho do bloco não importa, pois os arquivos VMDK permanecem os mesmos.
O sistema operacional convidado permanecerá praticamente intacto, mas solicitará que você configure os recursos ao adicionar o servidor novamente. Quando o servidor voltar, ele não deverá causar nenhum problema
Aqui está uma lista de etapas modificadas de Spiceworks :
Connect with vSphere directly to the host it was running on, right-click the server and choose “Remove from >Inventory.”.
Browse the datastore it was on and single click the folder which has the vmdk's and vmx in.
Click on the "Download a file from this datastore to your local machine" and save it somewhere you will >remember.
Connect with vSphere directly to the host you want it to run on and browse the datastore of the disk/raid you >want it on.
Single click the root of the datastore and click "Upload files to this datastore" and select the previously >downloaded folder.
Once the file is uploaded go into the folder on the datastore and right click the VMX file and choose "Add to >Inventory".
Follow the on screen instructions. This will be asking you for Name of the server and resource pool.
When you turn on the VM you will see a message saying msg.uuid.altered, click on "I moved it".
Como é um computador, tudo pode dar errado. Certifique-se de ter um backup.