Há um artigo da KB que aborda problemas de memória / falhas do Adobe Reader:
Erros e congelamentos - Adobe Reader - Windows
Different factors can cause system errors, including conflicts among device drivers, software, and hardware, and corrupt elements in specific files. Although a system error may occur only when you work with Adobe Reader, Adobe Reader may not necessarily be the cause--it may be the only application that is memory- or processor-intensive enough to expose the problem.