Se sua ênfase está na compatibilidade máxima para o seu drive USB, eu uso exFAT no meu.
Like NTFS, exFAT has very large file size and partition size limits. This means you can store files that are larger than 4 GB apiece on a flash drive or SD card if it’s formatted with exFAT. exFAT is a strict upgrade over FAT32, and should be the best choice for external drives where you want a lightweight file system without FAT32’s file size limits.
exFAT is also more compatible than NTFS. While Mac OS X includes only read-only support for NTFS, Macs offer full read-write support for exFAT.
( Fonte )