Deve ser seguro, mas não pode garantir isso. A partir dos documentos do kernel:
min_free_kbytes:
This is used to force the Linux VM to keep a minimum number
of kilobytes free. The VM uses this number to compute a
watermark[WMARK_MIN] value for each lowmem zone in the system.
Each lowmem zone gets a number of reserved free pages based
proportionally on its size.
Some minimal amount of memory is needed to satisfy PF_MEMALLOC
allocations; if you set this to lower than 1024KB, your system will
become subtly broken, and prone to deadlock under high loads.
Setting this too high will OOM your machine instantly.
Essencialmente, se você configurá-lo para baixo, você terá problemas com a alocação de memória.