Não, o Qubes OS não suporta OpenGL ou qualquer gráfico acelerado de qualquer tipo em uma VM. O documento localizado no link afirma:
Can I run applications, like games, which require 3D support?
Those won’t fly. We do not provide OpenGL virtualization for Qubes. This is mostly a security decision, as implementing such a feature would most likely introduce a great deal of complexity into the GUI virtualization infrastructure. However, Qubes does allow for the use of accelerated graphics (OpenGL) in Dom0’s Window Manager, so all the fancy desktop effects should still work.